General Virology and DNA Viruses
HPV-related cervical intraepithelial neoplasia can be diagnosed by the presence of which of the following histologic features?
|A||Central, basophilic intranuclear cellular inclusions|
|B||Cowdry type A intranuclear cellular inclusions|
|C||Enlarged multinucleated cells|
|D||Cytoplasmic vacuolization and nuclear enlargement of cells|
a. HPV produces characteristic cytoplasmic vacuolization and nuclear enlargement of squamous epithelial cells, referred to as koilocytosis; answers A, B, C, and E are incorrect: Both Cowdry type A intranuclear inclusions and enlarged multinucleated cells can be seen with herpes simplex virus (HSV) and varicella-zoster virus (VZV)
b. infections; central, basophilic intranuclear inclusion bodies are seen in CMV infections, whereas the presence of atypical lymphocytes is seen specifically in Epstein-Barr virus (EBV) infections.