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Medicine

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Hematology

Question
8 out of 19
 

HbA2 levels are increased in all Except: (PGI May 2009)



A Alpha Thalassemia
B Beta Thalassemia

C Sickle cell anemia
D Megaloblastic Anemia.

Ans. B

Beta Thalassemia

Alpha–Thalassanemia

There are four alpha genes in chromosome 16 in normal individuals. Both sexes are affected. It may present as hydrops fetalis (all genes deleted) or hemoglobin H (3 genes deleted), or mild hypochromic microcytic anemia (2 genes deleted) or asymptomatic (1 gene deleted).

Alpha – Thalassanemia

1. Cause:

a. Failure of production of hemoglobin alpha chains due to gene deletion

2. Presentation

a. Hydrops fetalis if all genes deleted

b. Hemoglobin H if three genes deleted

c. Mild hypochromic microcytic anemia if two genes deleted

d. Asymptomatic if one gene is affected.

3. Treatment

a. Hydrops fetalis: None available

b. Hemoglobin H: No specific therapy required; avoid iron therapy. If folic acid is given

Hematology Flashcard List

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