HbA2 levels are increased in all Except: (PGI May 2009)
|C||Sickle cell anemia|
There are four alpha genes in chromosome 16 in normal individuals. Both sexes are affected. It may present as hydrops fetalis (all genes deleted) or hemoglobin H (3 genes deleted), or mild hypochromic microcytic anemia (2 genes deleted) or asymptomatic (1 gene deleted).
Alpha – Thalassanemia
a. Failure of production of hemoglobin alpha chains due to gene deletion
a. Hydrops fetalis if all genes deleted
b. Hemoglobin H if three genes deleted
c. Mild hypochromic microcytic anemia if two genes deleted
d. Asymptomatic if one gene is affected.
a. Hydrops fetalis: None available
b. Hemoglobin H: No specific therapy required; avoid iron therapy. If folic acid is given