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Anemia of chronic disease 

  1. ↓ EPO
  2. Bone marrow suppression- due to release of TNF and IL-I
  3. Defective iron metabolism (defective iron release from tissue into the plasma)
  4. RBC life span moderately  

Lab

  1. Initially Normocytic & Normochromic later on Hyperchromic microcytic anemia
  2. Hypochromic microcytic anemia
     
    ↓ serum iron
  3. ↓ / N TIBC
  4. S. ferritin level
  5. S. transferrin receptor (TFR) level normal TFR / ferritin
  6. Differential diagnosis of microcytic Hypochronic anemia

 

Iron deficiency anemia

Beta-thalassemia trait

Anemia of chronic disease

Sideroblastic anemia

Serum iron

N

TIBC

N

N

Serum Ferritin

N

Red cell protoporphyrin

N

 or N

Hemoglobin A2

N

Marrow iron

Absent

Present

Present

Present





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