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Hereditary Methemoglobinemia

  1. Oxygen transport depends on the maintenance of intra cellular hemoglobin in the reduced (Fe+2) and is now in capable to binding oxygen.
  2. Hereditary methemoglobinemia is due to either the presence of one of the M hemoglobins or to the deficiency of the enzyme cytochrome b5 reductase.
  3. Lf me, hemoglobin exceeds gm% (% of the total Hb) affected individual which have clinically obvious cyanosis. 


  1. Methylene blue
  2. Ascorbic acid

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