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Medicine

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Hematology

Question
25 out of 34
 

Hemoglobin F is raised in: (AIIMS Nov 09)



A Juvenile chronic myeloid leukemia

B Hereditary spherocytosis

C Congenital red cell aplasia

D Myasthenia gravis

Ans. A

Juvenile chronic myeloid leukemia

Causes of raised HbF:

1. Juvenile CML

2. β thalassemia

3. Sickle cell anemia

4. Heriditary persistence of fetal hemoglobin (HPFF)

Difference between Juvenile and Adult CML

Note: In Juvenile CML Philadelphia chromosome is negative

The symptoms of CML

1. Insidious onset.

2. Tiredness, anorexia and abdominal discomforts are the common complaints.

3. Weight loss and excessive sweating

4. Visual disturbance and venous thrombosis.

5. Pallor.

6. Massive splenomegaly

7. Hepatomegaly.

8. Lymphadenopathy is not a feature of CML. (MCQ)

9. Priapism - A few male patients may present with painful, penile erection due to leukostasis.

Leucostatic manifestation due to severe leucocytosis or thrombocytosis

1. Vaso occlusive disease

2. CVA

3. MI

4. Venous thrombosis

5. Priapism

6. Visual disturbance

7. Pulmonary insufficiency.

Hematology Flashcard List

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