60 out of 100
Hemorrhagic cystitis is caused by (DNB Dec 2009)
Ans. A Cyclophosphamide
- Cyclophosphamide belongs to alkylating class of drug.
- It is a prodrug, activated to aldophosphamide after action of CYP450
- Aldophosphamide when reaches at the tissue level, will get converted to two equilibrium forms: acrolein and phosphamide mustarD.
- It is the acrolein, which result in hemorrhagic cystitis as its side effect and phosphamide mustard will cause neurotoxicity.
- MESNA is the agent , preferably been given by oral route, can be used to prevent hemorrhagic cystits.
- Other side effects of cyclophosphamide are cardiotoxicity and SIADH.
- It also produces side effects which are common to all alkylating agents:
Mnemonics: (LG STAMP)
L- Leukemia (secondary)
G- GIT toxicity (nausea, vomiting, diarrhea)
A – Alopecia
M – Myelosuppression
P- Pulmonary toxicity