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Medicine

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Hematology

Question
4 out of 21
 

Hodgkin's lymphoma of the nodular subtype is associated with: (AIIMS May 2011)



A Lacunar cells
B Popcorn cells

C Reticular variant
D None of the above

Ans. A

Lacunar cells

Lymphoma are disorder of malignant proliferation of lymphocyte. They accumulate in lymph node and cause lymphadenopathy. They are also found in PBF and may infiltrate many other organs.

HODGKIN'S DISEASE

1. Incidence. This neoplasm has a characteristic bimodal age distribution.

a. A young adult peak occurs between the ages of 10 and 25 years and is character­ized by equal incidence in men and women, a preponderance of nodular scle­rosis pathology, and a more benign clinical course.

b. A second adult peak occurs after age 50 years and is characterized by high inci­dence among men, a preponderance of mixed cellularity, and a more aggressive clinical course.

2. Pathology. There are four major histologic variants of Hodgkin's disease.

Hodgkin's Disease

Classical Hodgkin’s disease

Histogenetically distinct subtype of Hodgkin’s disease

Variants/ subtypes

Variant / subtype

Mixed cellularity, Nodular sclerosis,

Lymphocyte Rich, Lymphocyte depletion

Lymphocyte predominant (Nodular lymphocyte predominant)

Characterized by

Characterized by

Frequent Reed Sternberg cells

Characteristic immunophenotype

1. CD 15 positive: ii. CD 30 positive

2. CD 45 negative

Rare Reed Sternberg cells (Frequent lymphocytic and histocytic variants (Popcorn cells)

Characteristically different immunophenotype

1. CD 15 negative ii. CD 30 negative

2. CD 45 positive

Note:

1. Lymphocytic predominant is a distinct subtype.

2. Most common in India is mix cellularity

3. Most common in world is nodular sclerosing

4. Classical marker is Hodgkin’s disease are CD15, CD30

Clinical features and staging. Hodgkin's disease tends to spread in an orderly fashion from node group to node group. This contiguous nature is in marked contrast to non Hodgkin's lymphomas, which are multicentric early in their development. Pal Epstein fever occurs. There is pain less rubbery enlargement of lymph node occur. Alcohol causes increase in symptom (PGI Dec 2008).

Hematology Flashcard List

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