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Medicine

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Liver & GIT

Question
24 out of 27
 

Hypergastrinemia with hypochlorhydria is seen in: (LQ)



A Zollinger Ellison Syndrome
B VIPoma

C Pernicious anemia
D Glucagonoma

Ans. C Pernicious anemia

Diagnosis of ZES:

1. Fasting gastrin level.

Fasting gastrin levels are usually <150 pg/mL. Virtually all gastrinoma patients have a gastrin level > 150-200 pg/mL.

Extra Edge Other causes of elevated fasting gastrin level.

a. Gastric hypochlorhydria or achlorhydria (the most frequent), with or without pernicious anemia;

b. Retained gastric antrum;

c. G cell hyperplasia;

d. Gastric outlet obstruction;

e. Renal insufficiency;

f. Massive small-bowel obstruction;

g. Conditions such as rheumatoid arthritis, vitiligo, diabetes mellitus, and pheochromocytoma.

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