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Medicine

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Kidney

Question
4 out of 4
 

Hyperkalemia occur in (AIIMS May 07)



A Bartter

B Liddle

C Gitelman

D Gordon syndrome

Ans. D Gordon syndrome

A. Liddle’s syndrome (AIIMS Nov 07)

1. This disorder is due to unregulated sodium reabsorption by an overactive EnaC in the cortical collecting duct. It is characterized by:

i. The presence of early and severe hypertension

ii. Hypokalemia and metabolic alkalosis,

iii. Plasma aldosterone and renin levels are low.

2. Increased potassium and hydrogen ion secretion follow the lumen-negative electrical potential that result from chloride independent sodium reabsorption.

3. Amiloride or triamterene block EnaC (Amiloride sensitive epithelial Na channel) and, combined with salt restriction, provide effective therapy for hypertension and hypokalemia.

B. Familial hyperkalemic hypertension (FHHt) (Pseudohypoaldosteronism type II; Gordon syndrome) (AIIMS May 07)

FHHt is a rare autosomal dominant disease that manifests early adulthood with

a. Thiazide-responsive, low-renin hypertension b. hyperkalemia c. Metabolic acidosis d. Normal renal function.

Pathophysiology

Enhanced salt reabsorption in the DCT and impaired distal secretion of potassium and hydrogen ion,

Rx: Thiazide diuretics.

Summary

K

Metabolic

BP

S. Aldosterone

Bartter

Alkalosis

N

Gitelman

Alkalosis

N

Liddle

Alkalosis

High

Gordon

Acidosis

High

Summary of “the Summary” in just two lines !!!

1. Hyperkalemia, Metabolic acidosis occur in Gordon.

2. High BP and low level of serum aldosterone occur in Gordon and Liddle.