Hypertrophic gastropathy is seen in - (PGI Dec 09)
|A||Seen in menetriers disease and ZES|
|B||It is associated with malignancy|
|C||It shows cerebriform rugacity on stomach|
|D||More in fundus and body|
a. Hypertrophic gastropathy is a group of uncommon conditions, all characterized by giant cerebrifrom enlargement of the rugal folds of the gastric mucosa.
b. The rugal enlargement is caused by hyperplasis of the mucosal epithelial cells, without inflammation.
Three variant are recognized
i. Menetrier disease→ Resulting from profound hyperplasia of the surface mucous cells with accompanying glandular actrophy.
ii. Hypertrophic – hypersecretory → Associated with hyperplasia of the parietal and chief cells gastropathy within gastric glands.
iii. Zollinger – Ellison syndrome → Gastic gland hyperplsia due to excessive gastrin secretion by gastrinoma.
c. Ménétrier disease may involve predominantly the body - fundus or antrum or the entire stomach.
d. Mucosal hyperplasia may becomes metaplastic, providing a soil for the development of gastric carcinoma.