Hypospadias in the baby is caused by maternal use of which of the following drug? (AI 2012)
The drugs that have been associated with high incidence of hypospadias include:
a. Valproic acid Phenytoin Progesterone (often given to mothers as part of IVF treatment)
b. Diethylstilbestrol (prescribed up until the 1970s to prevent miscarriage)
c. Clomiphene (used to induce ovulation during IVF treatment)
d. From the above information, in this question also there are two answers i.e. DES and clomiphene. As we have to choose one, we will go with clomiphene because it is being commonly used these days for fertility induction whereas diethylstilbestrol is rarely used now-a-days.
e. Further surgery books write that "Incidence of hypospadias is now increasing predominantly because of use of drugs to promote fertility. "
f. Clomiphene is associated with increased risk of neural tube defects and hypospadias in the newborn babies.