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Pharmacology

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Question
18 out of 45
 

If this patient undergoes a percutaneous coronary procedure and placement of a stent in a coronary blood vessel, she may be given eptifibatide. The mechanism of eptifibatide anti clotting action is(LQ)



A Activation of antithrombin III

B Blockade of posttranslational modification of clotting factors

C Inhibition of thromboxane production

D Irreversible inhibition of platelet ADP receptors

E Reversible inhibition of glycoprotein IIb/IIIa receptors

Ans. E Reversible inhibition of glycoprotein IIb/IIIa receptors

a. Eptifibatide is a reversible inhibitor of the glycoprotein lIb/IlIa receptor, an integrin on the surface of platelets that serves as a key regulator of platelet aggregation. Glycoprotein lIb/IlIa receptor antagonists help to prevent platelet-induced occlusion of coronary stents.

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