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Dendritic Cells

  1. Present in lymphoid tissues & non-lymphoid organs (lungs. heart.
  2. Skin  Langerhans cells)Q
  3. Interdigitating DCs - Non-phagocytic, express high levels of MHC-II molecules & B7-1, B7-2 Antigen presenting: most potent Ag presenting cells for T cells: seen in lymphoid, non lymphoid organs such as heart lung.

Several features of dendritic cells account for their key role in antigen presentation.

  1. First, these cells are located at the right place to capture antigens-under epithelia, the common site of entry of microbes and foreign antigens, and in the interstitia of all tissues, where antigens may be produced. Immature dendritic cells within the epidermis are called Langerhans cells.
  2. Second, dendritic cells express many receptors for capturing and responding to microbes (and other antigens), including TLRs and mannose receptors.
  3. Third, in response to microbes, dendritic cells are recruited to the T-cell zones of lymphoid organs, where they are ideally located to present antigens to T cells.
  4. Fourth, dendritic cells express high levels of the molecules needed for presenting antigens to and activating CD4+ T cells.
  5. The chief antigen-presenting cells are macrophages and stellate-shaped dendritic cells.
  6. Dendritic cells arise from stem cells in the bone marrow, but migrate through the blood and lymph to almost every tissue.
  1. Follicular DCs
    1. Present in Germinal centres of lymphoid follicles
    2. Bear Fc receptors for IgG. trap Ag bound to Ab
    3. Role in ongoing immune response AIDS

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