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Anatomy

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Histology

Question
26 out of 59
 

In Acute inflammation, the mediator for migration and attachment of neutrophils to the endothelium is (LQ)



A Adhesins
B Integrins

C Perforins
D Opsonins

E Selectins

Ans. E

Selectins

1. Selectins are a family of cell-surface adhesion molecules of leukocytes and endothelial cells.

2. During an inflammatory response stimuli such as histamine and thrombin cause endothelial cells to mobilize P-selectin from stores inside the cell to the cell surface.

3. In addition, cytokines such as TNF-alpha stimulate the expression of E-selectin and additional P-selectin a few hours later.

4. As the leukocyte rolls along the blood vessel wall, the distal lectin-like domain of the selectin binds to carbohydrate groups presented on proteins (such as PSGL-1) on the leukocyte, which slows the cell and allows it to leave the blood vessel and enter the site of infection/inflammation.

Histology Flashcard List

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