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Surgery

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Mediastinum

Question
16 out of 28
 

In Burkitt's lymphoma, cell involvement is



A T cell
B B cell

C E and B cell
D Plasma cell

Ans. B B cell ( REF. HARRISON INTERNAL MEDICINE 18TH EDN CHP 105, PG 287-302.)

a. Burkitt's lymphoma/leukemia is a rare disease in adults in the United States, making up <1% of non-Hodgkin's lymphomas, but it makes up ~30% of childhood non-Hodgkin's lymphoma. Burkitt's leukemia, or L3 ALL, makes up a small proportion of childhood and adult acute leukemias

b. Three distinct clinical forms of Burkitt's lymphoma are recognized; endemic, sporadic, and immunodeficiency-associated.

c. Endemic and sporadic Burkitt's lymphomas occur frequently in children in Africa, and the sporadic form in western countries.

d. Immunodeficiency-associated Burkitt's lymphoma is seen in patients with HIV infection.

e. The disease is rapidly progressive and has a propensity to metastasize to the CNS. Initial evaluation should always include an examination of cerebral spinal fluid to rule out metastasis in addition to the other staging evaluations.

f. Once the diagnosis of Burkitt's lymphoma is suspected, a diagnosis must be made promptly and staging evaluation must be accomplished expeditiously.

g. This is the most rapidly progressive human tumor, and any delay in initiating therapy can adversely affect the patient's prognosis

h. Treatment of Burkitt's lymphoma in both children and adults should begin within 48 h of diagnosis and involves the use of intensive combination chemotherapy regimens incorporating high doses of cyclophosphamide.

i. Prophylactic therapy to the CNS is mandatory.

j. Burkitt's lymphoma was one of the first cancers shown to be curable by chemotherapy.

Mediastinum Flashcard List

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