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Paediatric

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Nutrition And Nutritional Disorders

Question
40 out of 49
 

In Scurvy, all are seen except (AIIMS May 2009)



A Bowing of legs in children

B widening of epiphysis

C sicca syndrome in adults

D Defect in zone of provisional calcification

Ans. B

widening of epiphysis

1. Zone of provisional calcification is The junction of the mineralizing metaphysis with the cartiliginous physis in growth plate. In scurvy in this zone white line of frankel is formed due to excessive mineralization of less collagen laid (Vit C lays down collagen in this zone). widening of epiphysis occurs in Rickets.

2. Costochondral junctions of the first 6 or 8 thoracic ribs may be expanded; this change may be related to fracturing of the zone of provisional calcification during normal respiration. Zone of provisional calcification is seen in rickets and not scurvy as there is excess deposition of unmineralized osteoid in rickets

3. Scurvy, a state of dietary deficiency of vitamin C (ascorbic acid).

4. Vitamin C is required for collagen synthesis, and vitamin C deficiency results in impaired collagen synthesis.

5. Defective collagen synthesis leads to

a. Defective dentine formation

b. Hemorrhaging into the gums

c. Loss of teeth.

d. Hair follicles are one of the common sites of cutaneous bleeding.

6. Hemorrhage is a hallmark feature of scurvy and can occur in any organ.

7. The bone changes are often observed only in infants during periods of rapid bone growth

8. The bony changes occur at the junction between the end of the diaphysis and growth cartilage.

9. Osteoblasts fail to form osteoid (bone matrix), resulting in cessation of endochondral bone formation.

10. Calcification of the growth cartilage continues at the end of long bones, leading to the thickening of the growth plate.

11. Preexisting bone becomes brittle and undergoes resorption at a normal rate, resulting in microscopic Fractures between the shaft and calcified cartilage.

12. These fractures, result in the subperiosteal hemorrhage at the ends of the long bones.

13. Hyperkeratosis, corkscrew hair, and sicca syndrome are typically observed in adult scurvy but rarely occur in infantile scurvy.

Bowing of legscan occur due to fractures.

Nutrition And Nutritional Disorders Flashcard List

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