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Medicine

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Neurology

Question
12 out of 18
 

In Shy Drager syndrome is Parkinson + which of the following neuropathy? (AIIMS May 2011)



A Motor
B Sensory

C Autonomic
D All

Ans. C

Autonomic

B. Multisystem atrophy (Shy dragger syndrome)

The features are as follows:

1). Parkinsonism

2. Autonomic neuropathy

3). Cerebellar ataxia (due to olivo ponto cerebellar atrophy)

Additional feature which may be there are – Dystonia, Myoclonus, Emotional incontinence, Sleep deprivation.

Pathology: There is presence of alpha Synuclein positive inclusion located in the various part of the brain.

New Drug: Not given in Harison 18th ed. Also !!!

Droxidopa is a synthetic amino acid precursor which acts as a prodrug to the neurotransmitters norepinephrine (noradrenaline) and epinephrine (adrenaline). Unlike norepinephrine and epinephrine themselves, droxidopa is capable of crossing the protective blood–brain barrier (BBB)

Indications

1). Neurogenic orthostatic hypotension (NOH), as well as NOH associated with multiple system atrophy (MSA), familial amyloid polyneuropathy (FAP), pure autonomic failure (PAF), and Parkinson's disease (PD).

2). Intradialytic hypotension (IDH) or hemodialysis-induced hypotension.

3). Hypotension associated with fibromyalgia syndrome (FMS) and chronic fatigue syndrome (CFS)

Neurology Flashcard List

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