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Pathology

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Cell Injury

Question
21 out of 32
 

In apoptosis, Apaf-1 is activated by release of which of the following substances from the mitochondria? (LQ)



A Bcl-2
B Bax
C Bcl – XL
D Cytochrome C

Ans. D i.e., Cytochrome C [Ref Robbins 8th /e p. 29 & 7th/e p. 30]

Apoptosis is induced by a cascade of molecular events all of which culminate in the activation of caspases. 'In the cytosol cytochrome C binds to a protein called Apaf I (Apoptosis activating factor - 1) and the complex activates caspase 9'

Cell Injury Flashcard List

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