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Physiology

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Kidney

Question
21 out of 26
 

In collecting duct...



A increased excretion of K+

B increase excretion of Na+

C increase excretion of urea

D increased HCO3- reabsorption

Ans. A increased excretion of K+

There are 2 types of cells in cd

1.Principal cells

The principal cell mediates the collecting duct's influence on sodium and potassium balance via sodium channels and potassium channels located on the cell's apical membrane. Aldosterone increases the number of Na⁺/K⁺-ATPase pump that allow increased sodium reabsorption and potassium secretion. Vasopressin determines the expression of aquaporin channels on the cell surface

2. Intercalated cells

Intercalated cells come in α and β varieties and participate in acid-base homeostasis.

Type of cell

Secretes

Reabsorbs

α-intercalated cells

acid (via an apical H+-ATPase and H+/K+ exchanger) in the form of hydrogen ions

bicarbonate (via band 3, a basolateral Cl-/HCO3- exchanger)[7]

β-intercalated cells

bicarbonate (via pendrin a specialised apical Cl-/HCO3-)

acid (via a basal H+-ATPase)

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