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Biochemistry

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Carbohydrates

Question
17 out of 40
 

In fasting state, increased levels of alanine indicate (AIIMS Nov 2011)



A Increased breakdown of muscle protein

B Decreased utilization for gluconeogenesis

C Leak of alanine through plasma membrane

D Decreased uptake of alanine by liver for gluconeogenesis

Ans. A Increased breakdown of muscle protein

Harper Illustrated Biochemistry 29Ed ch 16

a. During the first few days of fasting, there is a rapid breakdown of muscle protein, providing amino acids that are used by the liver for gluconeogenesis.

b. [Note: Alanine and glutamine are quantitatively the most important gluconeogenic amino acids released from muscle. They are produced by the catabolism of branched-chain amino acids.]

c. By several weeks of fasting, the rate of muscle proteolysis decreases because there is a decline in the need for glucose as a fuel for the brain, which has begun using ketone bodies as a source of energy.

Carbohydrates Flashcard List

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