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Physiology

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Blood

Question
13 out of 42
 

In hemopoiesis G-CSF and GM-CSF causes:



A Leucopenia
B Granulocytosis

C Erythrocytosis
D Thrombocytosis

Ans. B Granulocytosis

Four glycoproteins that regulate the production of GRANULOCYTES and monocytes are secreted by different tissues of body and they are called colony stimulating factor.

• Granulocyte macrophage colony stimulating factor GM-CSF

• Granulocyte colony stimulating factor G-CSF

• Multipotent colony stimulating factor Multi-CSF

• Macrophage colony stimulating factor M-CSF

G-CSF and GM-CSF stimulate neutrophil production and are used in cancer patients. Q

• G-CSF: 5 pg/kg per day subcutaneously • Start 24-72 h after chemotherapy

• GM-CSF: 250 pg/m per day subcutaneously • Continue until absolute neutrophil count is 1 0,000/ml

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