Loading....
Coupon Accepted Successfully!

Microbiology

Open Flashcards

General Parasitology and Protozoa

Question
50 out of 90
 

In malaria, infective stage injected into human subjects by the mosquito is:



A Sporozoite
B Merozoite

C Cryptozoite
D Gametocyte

Ans. A Sporozoite

Man: intermediate host

a. Female anopheles mosquito: definitive host

b. In malaria infective stage for humans is sporozoites.

c. Human cycle (Schizogony/ asexual cycle): female anopheline mosquito bites sporozoites injected general circulation invade hepatocytes preerythrocytic schizogony merozoites invade rbcs erythrocytic schizogony some merozoites develop into gametocytes

d. Mosquito cycle (Sporogony/ sexual cycle): female anopheline mosquito bites picks macrogametocyte & microgametocyte exflagellation of microgametocyte penetrates one macrogamete zygote ookinete penetrates the epithelial lining & muscular wall & lies below the outer limiting membrane of the stomach oocyst sporocyst containing sporozoites rupture, sporozoites liberated in the body cavity reach salivary gland

Extra Edge: Possible targets of malaria vaccine

Extra Edge: Anti-malarial drugs susceptibility testing

Disease

Testing method

Remarks

Malaria

In vivo tests for patients with Plasmodium falciparum or P. Vivax malaria. Culture of erythrocytic stages of P. Falciparum.

Criteria for assessment are (i) microscopic examination (maturation from rings to schizonts; parasite multi plication), (ii) metabolic activity (incorporation of [3H] hypoxanthine; production of pldh, HRP2), and (iii) DNA quantification. PCR-based genetic analysis (mostly of Plasmodium falciparum) of mutations/amplification in genes putatively involved in resistance to chloroquine (pfcrt, pfmdr I), anrifolates (dhfr, dhps genes), atovaquone (cytochrome b gene), and others.

Drug resistance is a major problem, especially in P. Falciparum; it also occurs in P. Vivax.

Tests are used for epidemiologic assessment as well as for laboratory investigations.

Short-term culture test, are also described for erythrocytic stages of P. Vivax. On an experimental basis, there are in vitro tests to determine a drug's effect on liver stages and

Sexual stages (gametocytes).

General Parasitology and Protozoa Flashcard List

90 flashcards
1)
2)
3)
4)
5)
6)
7)
8)
9)
10)
11)
12)
13)
14)
15)
16)
17)
18)
19)
20)
21)
22)
23)
24)
25)
26)
27)
28)
29)
30)
31)
32)
33)
34)
35)
36)
37)
38)
39)
40)
41)
42)
43)
44)
45)
46)
47)
48)
49)
50)
51)
52)
53)
54)
55)
56)
57)
58)
59)
60)
61)
62)
63)
64)
65)
66)
67)
68)
69)
70)
71)
72)
73)
74)
75)
76)
77)
78)
79)
80)
81)
82)
83)
84)
85)
86)
87)
88)
89)
90)