In malignant hyperthermia the increased heat production is due to:
|A||Increi1sed muscle meti1bolism by excess of calcium ions|
|B||Thermic effect of food|
|C||Increased sympi1thctic discharge|
Increased muscle meti1bolism by excess of calcium ions
Malignant hyperthermia is abnormality of calcium release channel, ryanodine receptor, leading to accumulation of calcium and sustained contraction. During his sustained contraction there is hydrolysis of high anergy phosphates producing heat.