Male Genital Tract
In the testis intratubular germ cell neoplasia is seen in all, except: (AIIMS May 2013)
|C||Yolk sac tumor of testis|
Most testicular germ cell tumors originate from intratubular germ cell neoplasia (ITGCN).
ITGCN is seen adjacent to all germ cell tumors in adults except for spermatocytic seminoma and epidermoid and dermoid cysts. With rare exceptions, it is also not seen in pediatric tumors (teratomas, yolk sac tumors... Robbins 7th edition page 1096)
So, obviously friends, if we have to choose between options b and c, we would prefer option b as the answer. ITCGN is seen with a high frequency in the following conditions:
b. Prior germ cell tumors
c. Strong family history of germ cell tumor
d. Androgen insensitivity syndrome
e. Gonadal dysgenesis syndrome.
Untreated ITGCN progresses to invasive germ cell tumor in approximately 50% of cases over 5 years of follow-up.