Inclusions in oligodendrogliocytes is a feature of (AIIMS Nov 2010)
|D||Progressive multiple encephalopathy|
Progressive multiple encephalopathy
Progressive Multifocal Leukoencephalopathy
1). PML is a rare demyelinating CNS disorder caused by the reactivation of JC virus.
2). The virus stays latent in the kidneys and lymphoid organs until reactivation.
3). PML mainly occurs in adults with impaired cell-mediated immunity, especially AIDS patients but also in those with lymphoproliferative and myeloproliferative disorders. Decreasing immunosuppression in non-AIDS patents with PML (eg. Transplant patients).
4). JCV causes lytic infection of oligodendrocytes in the white matter. (AIPG 2011)
5). Symptoms include altered mental status, aphasia, ataxia, hemiparesis or hemiplegia and visual filed disturbances, Seizures.
6). Treatment: Risperidone and mirtazapine.
Important Points: Oligodendrocyte inclusion bodies are seen in PML (AIIMS Nov 2010)