Increased acetyl cholinesterase in amniotic fluid indicates (AIIMS Nov 2014)
A. Open neural tube defects B. Oesophageal atresia
C. Down syndrome D. Edwards’s syndrome
11a. False regarding myelomeningocele in children is: (LQ)
|B||Fecal and urinary incontinence|
|D||Neural tube defect|
[Open Neural Tube Defects]
11a. Ans. A.
1. NEURAL TUBE DEFECTS or dysraphism constitute a group of congenital abnormalities of CNS due to failure of neural tube to close spontaneously.
2. Myelomeningocele constitutes the most severe form of dysraphism.
3. Folic acid deficiency is believed to play a role in its etiology.
4. There is a sac like cystic midline swelling present on the back which is covered by a thin membrane. It may be located anywhere along the neural axis but 3/4th of them are present in lumbosacral region. There is variable degree of LOWER Motor Neuron Paralysis of Lower Extremities along with sensory loss in perineal area and lower limbs.
5. Fecal and Urinary Incontinence may occur due to neurogenic bladder and bowel. HYDROCEPHALUS, CTEV and congenital dislocation of hip (CDH) may be associated with this condition.