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Biochemistry

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Purines, Pyrimidines and Nucleic Acid Metabolism

Question
1 out of 14
 

Increased serum uric acid levels occur in



A Von Gierke’s disease

B Lesch-Nyhan syndrome

C Leukemia

D All of the above

Ans. D all the above

Uric acid is produced due to catabolism of Purine (A+G)

a. Von Gierke’s disease (Type l —glycogenosis) due to deficiency of G-6-phosphatase.

b. C/f Hypoglycemia, Lactic acidosis, Hyperlipidemia, and Hypercalcemia. Purine over production and Hyperuricemia occurs secondarily to enhanced generation of the PRPP precursor ribose-5- phosphate

c. Lesch-Nyhan syndrome: an over production hyperuricemia with frequent uric acid Lithiasis and a bizarre syndrome of self-mutilation, is due to defect in Hypoxanthine —guanine phosphoribosyl transferase (HRPT), an enzyme of purine salvage.

d. Leukemia Hyperuricemia is due to over production (due to high turnover of cells)

e. Hyperuricemia occurs in Glycogenosis : - type I (von Gierk’s disease), Type III (Forbe’s or Conis disease) type V (Mc Ardle’ s synd.) and type VIII (Tarui’ s disease)

Purines, Pyrimidines and Nucleic Acid Metabolism Flashcard List

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