Coupon Accepted Successfully!



Skin biopsy is the most useful investigation e.g. in erythrodermic psoriasis.

The typical histopathology of psoriasis (non-pustular form) is characterized by:

  1. Regular elongation of the rete ridges with thickening in their lower portion.
  2. Elongation and edema of the papillae.
  3. Thinning of the suprapapillary portions of the stratum malpighii with the occasional presence of a very small spongiform pustule of Kogoj.
  4. The absence of granular layer
  5. Parakeratosis
  6. Presence of Munro microabscesses. (Stratum Corneum layer)
    1. Exacerbof Munro microabscesses. (Stratum Corneum layeration factors.
      1. Alcohol intake should be discouraged because there is a positive correlation between psoriasis and alcohol intake and alcohol induced liver problems may preclude patient from receiving effective systemic therapy in future.
      2. Medications such as lithium, salicylates, iodine, beta blockers, naprosyn and penicillin have been implicated in exacerbating psoriasis. ACE inhibitors, chloroquine
      3. 80% of patients with psoriasis find that sunlight improves their conditions but the rest may find no change or even exacerbation. However, sunburn is always a precipitating factor because the scalded area will heal with new crops of psoriasis (the Koebner's phenomenon).
      4. Streptococcal infection if persistent or carried in the deep tonsil crypts should be eradicated with a course of antibiotics.
    2. Treatment:
      1. Parameters to measure severity-
      2. PASI (Psoriasis area and severity index)
      3. PGA (Physician global assessment)
      4. NAPSI (Nail Psoriasis severity index)
    3. Topical
      1. Topical and systemic medications
      2. Light therapy
      3. Biologics
      4. Climatotherapy
      5. Investigational therapies

Test Your Skills Now!
Take a Quiz now
Reviewer Name