Infliximab contraindicated in: (DNB Dec 2011)
Infliximab is a chimeric monoclonal antibody and is a TNF-alpha receptor blocker.
Cases of Reiter syndrome have been successfully treated by anti-TNF alpha drugs like infliximaB. British Society for Rhematology recommends the use of this drug in psoriatic arthropathy. Long term benefits of using such a therapy include:
Anti-TNF alpha drugs are contraindicated in patients who are pregnant, those with active infection. It is also avoided in those with heart failure. Infliximab can produce SLE like illness and hence is avoideD. SLE produced by this drug often involves lungs and pleurA. It is treated by corticosterioids (BG Katzung, Basic and Clinical Pharmacology; 10th Edition’ 2007, pp-588).
(Mnemonics: Infliximab can produce SLE like illness and hence is avoided)