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Paediatric

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Metabolic Diseases

Question
2 out of 13
 

Injection Glucagon is effective for management of persistent hypoglycemia in all, except (AIIMS Nov 2013)



A Large for date baby

B Galactosemia

C Infant of diabetic mother

D Nesidioblastosis

Ans. B

Galactosemia

a. Glucagon is used to t/t hypoglycemia caused by hyperinsulinism.

b. Glucagon mainly acts by increasing hepatic Glycogenolysis and Gluconeogenesis

c. Hyperinsulinism is a feature of all the four conditions mentioned in the questions so Glucagon should have been effective in all these conditions, but it is not so. Glucagon does not have any effect on hypoglycemia in Galactosemic patients.

In Galactosemia liver is the first organ to be affected so there is no question of increased glycogenolysis and gluconeogenesis from the already damaged liver therefore Glucagon will be ineffective.

Metabolic Diseases Flashcard List

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