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Medicine

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Endocrine

Question
9 out of 28
 

Insulin + acarbose given to patient and hypoglycemia seen. What is the treatment? (AIIMS Nov 2010)



A Sucrose
B Maltase

C Glucose
D Galactose

Ans. C

Glucose

When acarbose used in combination with insulin or other insulin secretagogues (Sulfonylureas or repaglinide), hypoglycemia may occurs.

When used as monotherapy, acarbose and miglitol do not enhance insulin secretion and hence in overdose do not cause hypoglycemiaQ.

Treatment:

1). Hypoglycemia associated with the use of acarbose or miglitol plus insulin or a insulin secretagogue should be treated with oral glucose (dextrose) and not sucrose or other complex carbohydrates, which may be ineffective.

2). The hydrolysis of sucrose (can sugar) to fructose and glucose is inhibited by acarbose and thus products containing sucrose are unsuitable for the rapid correction of hypoglycemia.

3). Patient should be aware of the need to have a readily available source of glucose (dextrose, d-glucose) to treat hypoglycemic episodes.

4). In sever hypoglycemia, intravenous dextrose or glucagon injections may be required.

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