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Pathology

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The Endocrine System

Question
31 out of 32
 

Insulin increases glucose entry into skeletal muscle, adipose tissues and liver cells by: (AIIMS Nov 2014)



A Increasing the number of glucose transporter GLUT2 in all these tissues

B Increasing the number of GLUT4 in muscle and adi- pose tissue and glucokinase in liver cells

C Increasing the number of GLUT3 in skeletal muscle and adipose tissues and GLUT4 in liver cells

D Increasing the number of GLUT1 in muscle, GLUT3 in adipose tissues and GLUT4 in liver cells

Ans. B Increasing the number of GLUT4 in muscle and adipose tissue and glucokinase in liver cells

Insulin acts by binding to its receptor and stimurating intrinsic tyrosine kinase activitv, leading to receptor autophosphorylation and the recruitment of intracellular signaling molecules, such as insulin receptor substrates (IRS)' Activation of the phosphatidylinositol-3,-kinase (PI-3-kinase) pathway stimulates translocation of glucose transporters (e.g., GLUT4) to the cell surface, an event that is crucial for glucose uptake by skeletal muscle and fat. Activation of other insulin receptor signaling pathways induces glycogen synthesis, protein synthesis, Iipogenesis, and regulation of various genes in insulin-

responsive cells.

The Endocrine System Flashcard List

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