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Dermatology

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Blistering Diseases

Question
4 out of 32
 

Inter cellular IgG deposition in epidermis is seen in: (LQ)



A Pemphigus

B Sub corneal pustular dermatosis

C Bullus pemphigoid

D Dermatitis Herpetiformis

Ans. A
Pemphigus Ref: Roxburgh’s Common skin disease 17/e p.91;

In pemphigus vulgaris, acantholysis selectively involves the layer of cells immediately above the basal cell layer and IgG deposits are seen in suprabasal layer of epidermis…

Site of blister / vesicle formation

a. Intra Epidermal Blisters

i. Granular layer

1) Friction blister

2) Pemphigus foliaceous

3) Subcorneal pustular dermatosis

4) Staphylococcal skin scald syndrome / Bullous impetigo

ii. Spinous layer

1) Eczematous dermatitis

2) Herpes virus infection

3) Familial benign pemphigus

iii. Supra basal

1) Pemphigus vulgaris

2) Darier’s disease

iv. Basal layer

1) Erythema multiforme

2) Lupus erythematosus

3) Lichen planus

4) Epidermolysis bullosa simplex

b. Blisters at Dermal – Epidermal Junctions

i. Junctional (at the lamina lucida)

1) Junctional epidermolysis bullosa

2) Bullous pemphigoid

ii. Dermolytic (Below basal lamina)

1) Epidermolysis bullosa dystrophicus

2) Epidermolysis bullosa acquisita

3) Porphyria cutanea tarda

4) Dermatitis herpetiformis

Blistering Diseases Flashcard List

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