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Medicine

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Liver & GIT

Question
7 out of 13
 

Intrahepatic cholestasis of pregnancy occurs most likely at what time? (LQ)



A 1st trimester

B 2nd trimester

C 3rd trimester

D Can occur any time

Ans. C 3rd trimester

Pregnancy And The Liver (Ref. H-18thedi, Pg 60)

Pregnancy-Associated Liver Disease

These conditionals only occur during pregnancy, may recur in subsequent pregnancies, and resolve after delivery of the baby

Intrahepatic cholestasis of pregnancy

1. This usually occurs in the third trimester of pregnancy but can occur earlier;

2. It is associated with intrauterine growth retardation and premature birth, increase fetal mortality.

3. The condition characteristically presents with profound itching and cholestatic LFTs. But the bilirubin may be normal and the liver biochemistry may show raised liver enzymes.

4. Placental bile salt deposition contribute to progressive uteroplacental insufficiency.

5. Resolves typically within two weeks of termination of pregnancy but can reoccur in next pregnancy or with the use of OC.

6. Treatment is ursodiol.

Liver & GIT Flashcard List

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