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Physiology

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GIT

Question
19 out of 19
 

Intrinsic factor is secreted by: (AIIMS MAY 2010)



A Chief cell
B Parietal cell

C G cells
D None of the above

Ans. B Parietal cell Ref: Ganong - 23rd Ed–Page-45
  1. Parietal cells, or oxyntic cells, are the stomach epithelium cells that secrete gastric acid and intrinsic factor.
  2. Parietal cells produce gastric acid (hydrochloric acid) in response to histamine (via H2 receptors), acetylcholine (M3 receptors) and gastrin (CCK2 receptors).
  3. The histamine receptors act by increasing intracellular cAMP, whereas the muscarinic and gastrin receptors increase intracellular Ca2+ levels. Gastrin is more important indirectly by increasing histamine synthesis in ECL cell, as gastrin has no effect on the maximum histamine-stimulated gastric acid secretion.

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