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Physiology

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GIT

Question
3 out of 19
 

Intrinsic factor of castle is + in (AIPG 2009)



A Chief cells
B Fundus cells

C Goblet cells
D Parietal cells

Ans. D Parietal cells
  1. Characteristics of the Gastric Secretions

a. In addition to mucus-secreting cells that line the entire surface of the stomach, the stomach mucosa has two important types of tubular glands: oxyntic glands (also called gastric glands) and pyloric glands.

b. The oxyntic or Parietal (acid-forming) glands secrete hydrochloric acid, pepsinogen, intrinsic factor, and mucus.

c. The pyloric glands secrete mainly mucus for protection of the pyloric mucosa from the stomach acid.

d. They also secrete the hormone gastrin.

e. The oxyntic glands are located on the inside surfaces of the body and fundus of the stomach, constituting the proximal 80 per cent of the stomach.

f. The pyloric glands are located in the antral portion of the stomach, the distal 20 per cent of the stomach.

  1. Secretions from the Oxyntic (Gastric) Glands

A typical stomach oxyntic gland is composed of three types of cells: (1) mucous neck cells, which secrete mainly mucus; (2) peptic (or chief) cells, which secrete large quantities of pepsinogen; and (3) parietal (or oxyntic) cells, which secrete hydrochloric acid and intrinsic factor.

  1. Pyloric Glands—Secretion of Mucus and Gastrin

a. The pyloric glands are structurally similar to the oxyntic glands but contain few peptic cells and almost no parietal cells.

b. Instead, they contain mostly mucous cells that are identical with the mucous neck cells of the oxyntic glands.

c. These cells secrete a small amount of pepsinogen, and an especially large amount of thin mucus that helps to lubricate food movement, as well as to protect the stomach wall from digestion by the gastric enzymes.

d. The pyloric glands also secrete the hormone gastrin, which plays a key role in controlling gastric secretion.

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