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Physiology

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Kidney

Question
4 out of 7
 

Inulin clearance is equal to



A 55m1/min
B 625 ml/min

C 125m1/min
D 40 ml/min

Ans. C 125m1/min

I. Substances used to measure GFR:

The substance should be —

freely filtered

neither reabsorbed nor secreted

nontoxic

not metabolized by the body.

Eg.

a. Inulin: polymer of fructose, meets above these criteria in human and most animals and is extensively used to measure GFR

CINULIN= UINULIN X V

PINULIN

= l26ml/min

= GFR

b. 51Cr-EDTAis also used but inulin remains the standared substance. Q

c. Endogenous creatinine clearance is easy to measure (GFR) and is worth while index of renal function

d. NMS/319 other substances used to measure GFR are mannitol sorbitol, sucrose (I.V.), isothalamate, radioactive cobalt labelledvit. B12, radioiodine — labelledHypaque.

II. Effective RPF = 625 ml/min. = PAH clearance

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