Autocoids (Histamine and Serotonin)
Ketoconazole should not be given to a patient being treated with astemizole because (LQ)
|A|| Ketoconazole induces the metabolism of astemizole|
|B||Dangerous ventricular arrhythmias can occur|
|C|| Astemizole inhibits the metabolis m of ketoconazole|
|D||Astemizole antagonizes the antifungal action of ke- toconazole|
Ketoconazole, erythromycin and clarithromycin are potent inhibitors of microsomal enzymes. Astemizole, terfenadine and cisapride are the drugs that can block cardiac K+ channels at high concentration. If administered along with microso- mal enzyme inhibitors, these drugs can result in torsades de pointes, a serious polymorphic ventricular tachycardia.