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Biochemistry

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Lipid

Question
49 out of 63
 
Ans. A Fatty acid synthase C. citrate Lyase

a. Lipoprotein Apo — C — II is activator of Lipoprotein lipase

b. Insulin — acts on Insulin Receptor — that activate the Tyrosine Kinase activity of β-subunits. Probably in Insulin deficiency ‘Activity of Tyrosine kinase is decreased.

c. Starvation and Diabetes mellitus have almost same metabolic changes ie. due to Insulin deficiency and glucagon excess. Or ratio of Glucagon/Insulin: -

This Leads to following changes in enzyme activity: -

a. Activity of Enzymes of Glycogenesis, glycolysis and pyruvate oxidation — are decreased

b. Eg. Glycogen synthase, glucokinasephosphofructokinase, pyruvate kinase ., pyruvate dehydrogenase

c. Activity of the Enzymes of Gluconeogenesis are Increased: eg. pyruvate carboxylase phosphoenolpyruvatecarboxykinase, fructose 1,6-biphosphophatase , Glucose-6- phosphatase .

d. Activity of the Enzymes of Pentose phosphate — pathway and Lipogenesis are decreased:- eg G-6-P-dehydrogenase; 6-phosphogulconate de-Hase, Malic enzyme., ATP-citrate Lyase,acetyl Co A- carboxylase fatty acid synthase

a. ratio of Glucagon/Insulin ie in excess of glucagon and deficiency of Insulin as in starvation and DM →↑ed lipolysis due to ed activity of— hormone sensitive Lipase and activation of carnitine-palmitoyl-transferase system of mitochondrial membrane Leads to edketogenesis.

Lipid Flashcard List

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