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Pathology

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Kidney

Question
33 out of 60
 

Kimmelstiel-Wilson disease is diagnostic of: (AIPG 2011)



A Diabetic glomerulolerosis

B Hypertension benign.

C Malignant hypertension

D Amyloidosis

Ans. A Diabetic glomerulolerosis

a. Diabetic Glomerulosclerosis­

The renal involvement occur as:

i. Non-nephrotic proteinuria; nephrotic syndrome and chronic renal failure

ii. There is afferent arteriolar sclerosis and risk of papillary necrosis

b. Morphology

i. Nodular glomerulosclerosis (pathognomic) or intercapillary glomerulosclerosis or Kimmelstiel Wilson disease

ii. Capillary basement membrane thickening

iii. Diffuse glomerulosclerosis

iv. Fibrin cap

v. Capsular drop

This renal pathology is more frequent and severe and more progressive in insulin dependent diabetes mellitus.

a. Permanent renal damage can develop in as little as 5 years after diabetes mellitus.

b. The spilling of albumin into the urine and, more specifically, the spilling of very small levels of albumin ("microalbuminuria") are the best markers to date for significant diabetic nephropathy.

c. Hypertension often coexists with, and apparently favors the development of, microalbuminuria, but is not a specific marker for renal damage.

Kidney Flashcard List

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