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Medicine

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Hematology

Question
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Laboratory evaluation for the differential diagnosis of chronic myeloproliferative disorders includes all the following except- (AIIMS Nov 2012)



A Chromosomal evaluation

B Bone marrow aspiration

C Flow-cytometric analysis

D Determination of red blood cell mass

Ans. C

Flow-cytometric analysis

Myeloproliferative Disorders

These are a group of disorders characterized by proliferation of each or all of the precursors for myeloid elements – RBC, WBC and platelets.

Extra Edge: Myeloid erythroid Ratio:

It is the ratio of myeloid to erythroid precursors in bone marrow.

Normally it varies from 2:1 to 4:1.

An increased ratio is found in a. Infections b. CML c. Erythroid hypoplasia

Decreased ratio may mean a depression of leukopoiesis or normoblastic hyperplasia depending on the overall cellularity of the bone marrow.

Table - WHO Classification of Chronic Myeloproliferative Disorders (Ref. Hari- 18th ed., Pg. 898, table 108.1)

Chronic myelogenous leukemia

Chronic neutrophilic leukemia

Chronic eosinophilic leukemia

Polycythemia vera

Chronic idiopathic myelofibrosis

Essential thrombocythemia

Extra Edge: They may undergo transformation into acute leukemia.

Blood count reflects two processes

1. Proliferating cell line (may involve other myeloid elements also)

2. Marrow infiltration (may cause a decrease in normal cells0

Extra Edge:

1. Flow cytometry is not used in diagnosis

2. Flow cytometry is used in diagnosis of PNH.

3. MPD are diagnosed by BM examination.

Hematology Flashcard List

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