Laudanosine is metabolite of (LQ)
Metabolism of both atracurium and cisatracurium produces laudanosine as metabolite but cisatracurium produces very less amount metabolite.
Laudanosine – Epileptic foci
a. Because atracurium undergoes Hofmann elimination as a primary route of chemodegradation, not surprisingly one of the major metabolites from this process is laudanosine, a tertiary amino alkaloid reported to be a modest CNS stimulant with epileptogenic activityand cardiovascular effects such a hypotension and bradycardia.
b. The purported hypothesis being that the laudanosine produced from the chemodegradation of parent atracurium would cross the blood-brain barrier in sufficiently high enough concentrations that lead to epileptogenic foci.
c. Laudanosine is also a metabolite of cisatracurium which, because of its identical structure to atracurium, undergoes chemodegradation via Hofmann elimination in vivo.
d. Plasma concentrations of laudanosine generated are lower when cisatracurium is used.