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Anaesthesia

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Muscle Relaxant

Question
38 out of 73
 

Laudanosine is metabolite of (LQ)



A Cis atracurium
B Atracurium

C Pancuronium
D Gallamine

Ans. B

Atracurium

Metabolism of both atracurium and cisatracurium produces laudanosine as metabolite but cisatracurium produces very less amount metabolite.

Laudanosine – Epileptic foci

a. Because atracurium undergoes Hofmann elimination as a primary route of chemodegradation, not surprisingly one of the major metabolites from this process is laudanosine, a tertiary amino alkaloid reported to be a modest CNS stimulant with epileptogenic activityand cardiovascular effects such a hypotension and bradycardia.

b. The purported hypothesis being that the laudanosine produced from the chemodegradation of parent atracurium would cross the blood-brain barrier in sufficiently high enough concentrations that lead to epileptogenic foci.

c. Laudanosine is also a metabolite of cisatracurium which, because of its identical structure to atracurium, undergoes chemodegradation via Hofmann elimination in vivo.

d. Plasma concentrations of laudanosine generated are lower when cisatracurium is used.

Muscle Relaxant Flashcard List

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