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Medicine

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Neurology

Question
20 out of 23
 

Localised regional cerebral atrophy is seen in: (PGI Nov 2013)



A Alzheimer's disease
B Frontotemporal dementia

C PML
D C. J. disease

E Friedreich's ataxia

Ans. B

Frontotemporal dementia

Extra Edge:- Fronto-temporal dementia (chromosome-17) is characterized by localized or regional atrophy of the temporal and or frontal lobe. 'The distinguishing anatomical hallmark of Frontotemporal dementia is a marked lobar atrophy (regional atrophy) of temporal and/or frontal lobe'

Condition

Anatomical Feature

Frontotemporal dementia

Regional (Localized) Atrophy of temporal and/or frontal lobe

Alzheimer’s disease

Diffuse cerebral atrophy

PML

Widespread demyelinating lesions of cerebral cortex

C. J. disease

Widespread neuronal loss and gliosis

Friedreich’s Ataxia

Cerebral cortex is usually not involved.

Involvement is primarily restricted to spinal cord, brainstem and cerebellum.

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