Long chain fatty acid transported through inner mitochondria membrane by
|A||Acyl carrier protein|
During oxidation of Fatty acids in mitochondria: -
a. Long chains fatty acids penetrate the inner mitochondrial membrane as carnitine derivatives.
b. Carnitine is synthesized from Lysine and methionine in liver and kidney.
c. Activation of the lower acids and their oxidation within the mitochondria may occur independently of carnitine.
d. But, Long chain Acyl CoA activated Long chain fatty acids will not penetrate the inner membrane of mitochondria and become oxidized unless they from “Acyl carnitine.
e. An enzyme, carnitinepalmitoyltransferase I present in the outer mitochondrial membrane, converts long chain Acyl CoA activated F.A to Acyl carnitine, which is able to penetrate the inner membrane of mitochondria and gain access to the β-oxidation system of enzymes.