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Medicine

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Respiratory

Question
6 out of 27
 

Lung to lung metastasis is most commonly seen in (AIIMS May 2010)



A Adenocarcinoma of lung

B Squamous cell carcinoma

C Small cell carcinoma

D Neuroendocrine tumor of lung

Ans. A

Adenocarcinoma of lung

Adenocarcinoma. (Robins, 7th edition, page 760-761)

1). This is a malignant epithelial tumor with glandular differentiation or mucin production by the tumor cells.

2). They show various growth patterns. Acinar, papillary, bronchioloalveolar, and solid with mucin formation.

3). About 80% contain mucin.

4). K-RAS mutations are seen primarily in adenocarcinoma

5). P53, RB, & p16 mutations and inactivation have the same frequency in adenocarcinoma as in squamous cell carcinoma.

6). Pure bronchioloalveolar growth pattern with no evidence of stromal, vascular, or pleural invasion.

7). Bronchioloalveolar carcinoma (BAC) is a subtype of adenocarcinoma that grows along the alveoli without invasion and can present radiographically as a single mass; as a diffuse, multinodular lesion; as a fluffy infiltrate; and on screening CT scans as a "ground glass" opacity. (Ref. Hari- 18th ed., Page 738)

8). The key feature of bronchioloalveolar carcinomas is their growth along preexisting structures with destruction of alveolar architecture.

9). This growth pattern has been termed “lepidic”, an allusion to the neoplastic cells resembling butterflies sitting on a fence.

10). It is located in the peripheral area of the lung.

Respiratory Flashcard List

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