Liver & GIT
Lynch syndrome associated with? (AIIMS Nov 09)
|A||Breast, colon, ovary|
|B||Breast, endometrium, ovary|
|C||Breast, colon, endometrium|
|D||Colon, endometrium, ovary|
a. Hereditary nonpolyposis colorectal cancer (HNPCC) is a colon cancer, characterised by a risk of other cancers of the endometrium, ovary, stomach, small intestine, hepatobiliary tract, upper urinary tract, brain, and skin. The increased risk for these cancers is due to inherited mutations that impair DNA mismatch repair.
b. HNPCC is also called Lynch syndrome, It is divided into Lynch syndrome I (familial colon cancer) and Lynch syndrome II(colorectal cancer and another type of cancer, usually, but not limited to, the gastrointestinal system or the reproductive system).