Gram Positive Bacilli
Main site of action of tetanus toxin-
|A||Presynaptic terminal of spinal cord|
|B||Post-synaptic terminal of spinal cord|
a. The neurotoxin, tetanospasmin acts at the inhibitory presynaptic neuroterminals in the spinal cord, preventing the release of GABA and glycine by proteolysing synaptobrevin that is responsible for the fusion of vesicles of neurotransmitters with the neuronal cell membranes.