Maintenance of a high urinary pH is important during methotrexate treatment in this patient because (LQ)
|A||Bladder irritation is reduced|
|B||It decreases renal tubular secretion of methotrexate|
|C||Leucovorin toxicity is increased in a dehydrated patient|
|D||Methotrexate is a weak acid|
a. Nephrotoxicity can be a problem with high doses of methotrexate, but it is less likely to occur than myelosuppression, especially if the patient is well hydrated and the urine is alkalinized.
b. MTX is a weak acid and is more water-soluble at alkaline pH; it is thus eliminated more rapidly in alkaline urine.