Major basic protein is formed by – (AIPG 2011)
· Eosinophils are the major participants in allergic responses and parasitic infestation.
· Eosinophils develop from stem cells in response to IL-5
· The major chemokine for eosinophils is eotaxin
· Eosinophils have a granule that contains major basic protein (MBP)
· Major basic protein has the following effect.
2. Toxic to parasites
3. Causes degranulation of mast cells.