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Major basic protein secreted by-
Ans. B basophils
- Proteoglycan 2 also called (natural killer cell activator, eosinophil granule major basic protein).
- PRG2 is a 117-residue protein that predominates in eosinophil granules.
- It is a potent enzyme against helminths and is toxic towards bacteria and mammalian cells in vitro.
- The eosinophil major basic protein also causes the release of histamine from mast cells and basophils, activates neutrophils and alveolar macrophages, and is directly implicated in epithelial cell damage, exfoliation and bronchospasm in asthma.
- eosinophils degranulate to release an array of cytotoxic granule cationic like:
a. Major basic protein (MBP)
b. Eosinophil cationic protein (ECP)
c. Eosinophil peroxidase (EPO)
d. Eosinophil-derived neurotoxin (EDN)